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CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a powerful genome editing technology that has revolutionized the field of genetic engineering. In recent years, CRISPR has emerged as a promising tool for the treatment and prevention of various genetic and non-genetic diseases. This review article provides an overview of the revolutionary role of CRISPR in disease treatment and prevention, covering various aspects of its application in diverse fields such as oncology, neurology, infectious diseases, and rare genetic disorders. We discuss the challenges and limitations of CRISPR, including off-target effects and delivery issues, as well as ethical considerations surrounding its use. Furthermore, we provide insights into the future of CRISPR-based therapies and highlight the potential of this technology for advancing precision medicine. In general, this review highlights the significant impact of CRISPR in disease treatment and prevention and emphasizes its potential to revolutionize the field of medicine in the coming years.